Jeff Who Lives at Home (AFI Fest 2011)

Jason Segel and Ed Helms have loads of comedic chemistry in this heartfelt story about two brothers trying to find their place in the world. Writer/director/brother team Mark Duplass and Jay Duplass (Cyrus, The Puffy Chair) have found their stride; they are able to artfully blend comedy and poignancy while making normal activities (like fixing a closet door) seem epic. The film also features Susan Sarandon, Rae Dawn Chong and Evan Ross in interesting supporting roles.
Dispatched from his basement room on an errand for his mother, slacker Jeff might discover his destiny when he spends the day with his brother as he tracks his possibly adulterous wife.
No trailer yet, but here's a video of the Q&A at the AFI Fest presented by Audi.

In theaters March 2012.